pFolMech

  Protein Biophysics Lab

Predicting Folding Free Energy Profiles, Conformational Landscapes, and Folding Mechanisms

General Instructions

  • The protein length should be between 50 – 500 amino acids (Visit help page for more details).

  • The uploaded PDB file
    • Should not contain any hetero atom(s) or non-standard amino acid(s).
    • Should contain the complete description of heavy atoms (To model missing atoms, visit here).
    • Should contain one structural state (i.e. one model entry) in case of NMR structures.

  • Large proteins (>100 amino acids) are approximated using a block definition of block size = ceil(nres/100), where nres corresponds to the number of residues in the protein.
    • For example, a protein of length 452 will be split into multiple blocks whose most probable block size is 5.
    • Maximum block size of 5 is used.

  • The effects of disulphide bridges are not accounted for by the web server.

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S U B M I T

2022, Maintained by Protein Biophysics Lab, IIT Madras, Chennai-36, India

Last Updated: February 8, 2022